The role of adipose tissue as an endocrine organ is clearly indicated by the secretion of adiponectin and other adipokines, affecting the cardiovascular system at both cellular and molecular levels; it is now known to have anti-apoptotic, anti-inflammatory, and antioxidant roles, hence reducing the pathogenic effects of cardiovascular disease (CVD), therefore it is described as a “rescue hormone”. Here, ADIPOQ is linked to cardiovascular disorder.