Foam cells form due to the accumulation of lipids in macrophages in atherosclerosis, and adiponectin demonstrated the ability to suppress lipid accumulation in macrophages, through the AdipoR1 and AdipoR2 and the APPL1 docking protein (APPL1 interacts directly with the intracellular region of AdipoR1 and AdipoR2 found on a cell membrane [66]). Here, ADIPOQ is linked to atherosclerosis.