On the other hand, it was uncovered that both the increase in adiponectin concentration and the increase in brain natriuretic peptide (BNP) increased mortality in patients with stable coronary artery heart disease (CAD), whereas the increase in adiponectin was not related to coronary revascularization, CV death, non-fatal myocardial infarction, or stroke [68]. This evidence concerns the gene NPPB and stroke disorder.