Effective treatment is yet to be found; although in T2DM and obesity, adiponectin was reported to be a cardioprotective adipokine that is downregulated, adiponectin signaling is also impaired due to the downregulation of both receptors (AdipoR1 and R2), leading to reducing cardio protection. This evidence concerns the gene ADIPOR1 and obesity due to melanocortin 4 receptor deficiency.