LEP and obesity due to melanocortin 4 receptor deficiency: The study noticed that MR-proADM was associated with (abdominal) obesity, through selected adipokines (retinol-binding protein-4, adiponectin, chemerin, and leptin), and subclinical inflammatory biomarkers (interleukin-1 receptor antagonist, interleukin-6, interleukin-22, myeloperoxidase, and high-sensitivity C-reactive protein) [18].