CCN5 and myeloid sarcoma: Among the top genes downregulated by ORY-2001, we found many genes described previously to be induced in EAE, such as those involved in antigen presentation (H2-Eb1, H2-Aa, A2m, B2m and others), complement factors (C3, C1qa, C1qb, C1qc), cytokines/chemokines (Ccl5, Ccl8, Il1b), microglial markers (Aif1, Cd68), factors involved in the breakdown of the blood brain barrier (Lgals3), modulators of demyelination/remyelination (Cst7, Lcn2, Mpz) or neuroprotection (Wisp2), in addition to drug targets for treatment of MS or related genes (Cd52, Itgax) (Figure 7a).