In addition, ORY-2001 but not FTY720 prevented the induction of Ptpn11, required for initial infiltration of pioneer CD8+ T-cells into the CNS in EAE [42], and of Kif1b and Pik3r1, associated with susceptibility to MS by GWAS [43] (Figure 9a,c). This evidence concerns the gene PIK3R1 and myeloid sarcoma.