Among the top genes downregulated by ORY-2001, we found many genes described previously to be induced in EAE, such as those involved in antigen presentation (H2-Eb1, H2-Aa, A2m, B2m and others), complement factors (C3, C1qa, C1qb, C1qc), cytokines/chemokines (Ccl5, Ccl8, Il1b), microglial markers (Aif1, Cd68), factors involved in the breakdown of the blood brain barrier (Lgals3), modulators of demyelination/remyelination (Cst7, Lcn2, Mpz) or neuroprotection (Wisp2), in addition to drug targets for treatment of MS or related genes (Cd52, Itgax) (Figure 7a). This evidence concerns the gene B2M and myeloid sarcoma.