TARDBP and amyotrophic lateral sclerosis: This system has a dual function: (1) the EPCs themselves repair the damaged BBB occurring in both ALS and AD–, and (2) transfected EPCs secrete, at the BBB, the anti-TDP-43 and anti-β-amyloid Fabs capable of solubilizing the aggregates of TDP-43 and β-amyloid.