Topological distribution of polarizability was identified as important for predicting the affinity of molecules against other targets such as mitogen-activated protein kinase-interacting kinases (MNK1, MNK2) [54] or apoptosis inducers for human breast cancer cell line T47D and human colorectal cancer cell line DLD-1 [55]. The gene discussed is MKNK1; the disease is breast cancer.