Studies performed in murine models of melanoma and in a spontaneous-orthotopic model of prostate cancer (TRAMP) have shown that NGR-TNF can increase tumor-tissue infiltration of either endogenous or adoptively transferred cytotoxic T-cells, without modification of T-cell distribution in blood, spleen or kidney in tumor-bearing mice [29]. The gene discussed is RTN4R; the disease is Familial prostate cancer.