INS and diabetes mellitus: An early-phase feasibility study using a Lilly hybrid closed-loop (HCL) system composed of an investigational insulin pump, insulin lispro, a pump-embedded model-predictive control algorithm, a continuous glucose monitor (CGM), and an external dedicated control results in a safe and satisfactory glycemic control in response to stimulated diabetes management challenges (NCT03849612, NCT03743285) [155].