The upregulation of G9a is involved in the progression of HCC by silencing various genes, including the proapoptotic genes, Bcl-G [164], MAP1LC3B (microtubule-associated protein light chain 3β), [165] and RARRES3 (retinoic acid receptor responder protein 3) [166]. The gene discussed is PLAAT4; the disease is hepatocellular carcinoma.