PKM and hepatocellular carcinoma: Many miR-122 targets involved in glucose metabolism have been related to HCC, such as aldolase A (ALDOA), citrate synthase (CS), glycogen synthase 1 (GYS1), glucose 6-phosphatase catalytic subunit 3 (G6PC3), and pyruvate kinase M2 (PKM2) (Figure 6) [17,20,64,180].