C4A and neoplasm: In another case, Warashina et al. developed a cationic lipid called YSK12-C4 and loaded it into NPs containing siRNA (YSK12-C4 multifunctional coated nano-device [YSK12-MEND]) to synthesize an efficient non-viral vector that can effectively transfer siRNA to DCs, significantly promote gene silencing in mouse DCs, and enhance tumor immunotherapy by regulating the expression of immunosuppressive genes [165].