Zeng and colleagues successfully encapsulated melanoma antigen peptide tyrosinase-associated protein 2 (Trp2) and Toll-like receptor-9 (TLR-9) agonist CpGODN in polymer hybrid micelles with a particle size smaller than 30 nm, which can effectively target proximal LNs, where their cargo can be effectively internalized by DCs and greatly expand antigen-specific cytotoxic T lymphocytes [124]. The gene discussed is TLR9; the disease is melanoma.