HER2-based PET tracers including 18F-HER2 aptamer [23], 68Ga- [24], and 64Cu-HER2 affibodies [25], 89Zr-trastuzumab [26], and 89Zr-pertuzumab [27,28] were applied for HER2-positive tumor detection in animal models and clinical studies. This evidence concerns the gene ERBB2 and neoplasm.