For this reason, the current study was based on the analysis of the molecular links of c-Myc/HIF-1α gene expression as well as on the expression of other markers such as c-Jun, ERK 1/2, pERK 1/2, VEGF, MMP-9, and Bcl-2, which are involved in Cal-27 survival/proliferation and tumor progression. Here, MMP9 is linked to neoplasm.