Furthermore, c-Fos is associated with lymphonoidal metastatic progression and poor differentiation, mainly in coexpression with c-Jun, especially the simultaneous co-expression of c-Jun/c-Fos/p53 in oral cell squamous carcinoma (OSCC) has been identified as a prognostic factor for survival [4]. The gene discussed is JUN; the disease is oral cavity squamous cell carcinoma.