Kilić discovered that although the intervention of NHE1-specific inhibitors only occurs in the initial period after either administration of hypertrophic stimulation of cultured cardiomyocytes or coronary artery ligation, it has substantial benefits for developing myocardial hypertrophy and left ventricular dysfunction after coronary artery ligation [78]. The gene discussed is SLC9A1; the disease is cardiac hypertrophy.