Certainly, all of the signaling pathways in our cells are involved in neoplasia development including PI3K/AKT, the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK), Wnt, the Janus kinase/signal transducer and activator of transcription (JAK/STAT), transforming growth factor beta 1 (TGF-β), Hippo (mammalian Ste20-like 1 and 2) kinase—yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif (Hippo—YAP/TAZ), Notch, and others [25]. Here, TGFB1 is linked to neoplasm.