Many known “switch-on” mutations of oncogenes, which are frequently observed in different neoplasia, lead to the constant activation of signaling pathways, including phosphoinositide 3-kinase/AKT serine/threonine kinase 1 (PI3K/AKT), Kirsten rat sarcoma virus/mitogen-activated protein kinases (Ras/MAPKs), Wnt family member 1, and others, which in turn drive and maintain cancer development. Here, AKT1 is linked to cancer.