NFE2L2 and Parkinson disease: In a mouse model of PD with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a toxin, oral administration of KMS99220 (10 and 30 mg/kg) attenuated motor dysfunction, protected dopaminergic neurons, and induced Nrf2 signalling [77].