The preliminary results of a phase I trial evaluating the safety and key pharmacodynamics and lipid parameters in patients with severe hypertriglyceridemia, ARO-APOC3 caused a maximal mean reduction of 80% to 99% in apo C-III levels, and a maximal mean reduction of 74% to 92% in plasma triglyceride levels. Here, APOC3 is linked to hypertriglyceridemia.