Melatonin can alleviate cardiovascular diseases such as atherosclerosis by regulating oxidative stress, endoplasmic reticulum stress, and the MAPK signaling pathway, et al. In the present study, we found that melatonin alleviated cardiomyocyte apoptosis in DCM via the lncRNA H19/miRNA-29c/MAPK axis. This evidence concerns the gene H19 and atherosclerosis.