We suggest that the advantage of melatonin is that it will not cause hypoglycemia, and that supplementary therapy with the use of hypoglycemic drugs such as insulin can further alleviate DCM by ameliorating oxidative stress, endoplasmic reticulum stress, and regulating MAPK signaling pathways, et al. We will further explore its advantages in future research. Here, INS is linked to familial dilated cardiomyopathy.