DF peptides and exercise act synergistically and attenuate the myocardial injury induced by spontaneous hypertension, possibly by regulating the energy metabolism signaling pathway (AMPK/SirT1/PGC-1α/FOXO3), as well as preventing myocardial fibrosis, hypertrophy, and apoptosis. This evidence concerns the gene SIRT1 and Myocardial fibrosis.