PLAU and hypertensive disorder: In our present study, DF treatment and exercise significantly reduced the expression of fibrotic protein markers such as uPA, CTGF, COL1A1, and COL3A1, as well as hypertrophy markers such as NFATC3, GATA4, BNP, and ANP, which indicates that it could attenuate hypertension-mediated myocardial injury.