NLRP3 and Parkinson disease: It was discovered that NEAT1 was increasingly expressed in PD mouse and cell models, targeting the miR-212-3p/AXIN1, miR-212-5p/RAB3IP, miR-124/KLF4, and miR-374c-5p axis to suppress viability and promote the release of IL-1β, IL-6, and other inflammation factors [173,174,175,176], similarly participating in neuroinflammation, NEAT1 serves as a stimulative role of α-syn-induced activation of the NLRP3 inflammasome by targeting miR-1301-3p/GJB1 [177].