Moreover, the lncRNA HOXA11-AS was overexpressed in an animal model of PD: MPTP (+)-induced NLRP3 inflammatory expression and LPS-induced microglial activation in a PD cell model was enhanced by HOXA11-AS and FSTL1 upregulation and/or miR-124-3p knockdown [50]. This evidence concerns the gene NLRP3 and Parkinson disease.