Curcumin triggered down-regulation on PKM2 via mTOR-HIF-1α inhibition in H1299 non–small cell lung cancer cells, MCF7 breast adenocarcinoma cells, HeLa cervical adenocarcinoma cells, and PC-3 prostate adenocarcinoma cells, reversing the Warburg effect [127]. This evidence concerns the gene MTOR and breast adenocarcinoma.