Previous studies have reported that quercetin can induce apoptosis of the breast cancer cell MCF-7 and the colorectal cancer cell HCT116 by modulating the AMPK/p38 pathway [34,35], implying that AMPK/p38 plays a critical role in triggering p53-independent apoptosis of cancer cells. The gene discussed is PRKAA1; the disease is breast carcinoma.