On the other hand, EFL2 (77) has a potent effect on hepatocellular carcinoma (HCC) and the study of its mode of action suggested that 77 inhibited TGF-β-induced migration and proliferation in HCC cells through the inhibition of phosphorylation of AKT and STAT3 [57]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.