As HIV-1 infection of target cells is a multistep process starting with attachment of viral glycoproteins (gp120/gp41) to host cell receptors (CD4 and CCR5 or CXCR4), fusion of viral envelope, reverse transcription, integration, and maturation of virions by killing target cells [21], it will be interesting to understand which of these steps are affected by treatment with 405 nm light, and this will be the focus of future studies. This evidence concerns the gene ITIH4 and HIV-1 infection.