Visceral adipose tissue would promote infiltration of macrophages and secretion of pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, interleukin-6, monocyte chemotactic peptide-1, and resistin) [24] and decrease adipocytokines secretion such as adiponectin that reduces insulin resistance and inflammation [25]. Here, RETN is linked to Insulin resistance.