Notch expression in the primary stage of CRC is relatively higher than in the later stage [82]; indeed, its activation is induced by several factors, including Matrix metalloproteinases-9 (MMP9) under inflammatory conditions, which in turn promotes the EMT (in particular involving TGF-β), NF-κB and Wnt signaling pathways, thus affecting the stability of β-catenin, MAPK and the nutrient sensor kinase mTOR [83]. This evidence concerns the gene TGFB1 and colorectal carcinoma.