The ability of TGR5 to lower the levels of pro-inflammatory cytokines in intestinal cells and macrophages has opened new insights into the modulatory role of BAs in diseases where inflammatory processes play a central role, such as CRC; however, its involvement in tumors has to be clarified since TGR5 seems to have different actions in different cell and tissue background. Here, GPBAR1 is linked to colorectal carcinoma.