NR1H4 and malignant colon neoplasm: Notably, in colon cancer cells, the constitutive activation of FXR can suppress colonic epithelium proliferation and induce the expression of a pro-apoptotic network of genes (p21, TNFα and the FAS receptor) while repressing anti-apoptotic genes, such as Bcl-2 [121], showing the high predisposition to intestinal adenocarcinoma due to decreased negative regulation of the FXR–FGF19 axis.