The process behind the silencing of FXR in CRC may lie in its DNA methylation caused by mutated APC that, in turn, leads to reduced expression of SHP and IBABP and induced cyclooxygenase-2 (COX-2) and c-Myc [123] and also by K-Ras signaling activation [115,124]. The gene discussed is PTGS2; the disease is colorectal carcinoma.