NR1H4 and intestinal cancer: So, there is a direct association between intestinal cancer incidence and FXR expression; indeed, the ileum has the greatest level of FXR expression [121], and it gradually decreases from the terminal ileum to the sigmoid colon, thus explaining the rare occurrence of carcinoma in the ileum and the highest incidence of carcinoma in the distal portions of the colon, which have low FXR expression levels [122].