NR1H4 and colorectal carcinoma: FXR is also involved in modulating other CRC-related pathways; for instance, the knockdown of FXR induces the expression of several EMT markers, such as vimentin, snail, slug, fibronectin, and MMP-9, while suppressing E-cadherin and zonula occludens-1 (ZO-1) [116].