NR1H4 and colorectal carcinoma: Moreover, in inflamed mouse colon tissue, the activity of FXR can be inhibited by the activation of NF-κB or peroxisome proliferator-activated receptor α (PPARα)–glucuronosyltransferases (UGT) axis activation, which was positively associated with the development of CRC [95] and negatively associated with the TGF-β-dependent pathway activation [125].