According to this, Sahu et al. showed that hesperidin supplementation with the same dosage for 10 days leads to decreased cisplatin (a cancer treatment known to induce nephrotoxicity)-induced levels of ROS and TBARS and increased activity of antioxidants (including SOD, GSH, CAT, GPx, GST, and glutathione reductase (GR)) in rat kidneys [106]. This evidence concerns the gene GSR and cancer.