The stress response and brain inflammation were suppressed by ingestion of green tea components with a CE/TA ratio of 2 or less one day after LPS administration; adrenal hypertrophy and brain inflammation were suppressed by ingestion of components with CE/TA ratios of 4 and 8 two days after LPS administration; and Npas4 was restored to suppressed expression with ingestion of components with a CE/TA ratio of 4. This evidence concerns the gene NPAS4 and hypertrophy.