SERPINE1 and type 2 diabetes mellitus: Considering that individuals with T2DM have elevated levels of plasminogen activator inhibitor-1 (PAI-1), implicated in the pathophysiology of CVD [120,121], and visceral adipose tissue is metabolically more active than subcutaneous adipose tissue producing more PAI-1 [122], a similar study was conducted on 51 individuals with well-controlled T2DM and no prior history of CVD investigating the relationship between two cardiovascular risk factors.