We may conclude that in the group of patients with CKD not treated with dialysis, OPG concentrations are significantly higher in individuals with EF < 50% and in those after myocardial infarction in the past in comparison with patients with EF ≥ 50% and those without a medical history of acute coronary syndrome (p = 0.044; p = 0.016). This evidence concerns the gene TNFRSF11B and chronic kidney disease.