In another study, treatment with γ-T3 activated the extrinsic apoptotic pathway in brain cancer cells through the upregulation of pro-apoptotic proteins, such as Bax, and TNF-related apoptosis-inducing ligand (TRAIL), Caspase-3, and Caspase-8 also induced cell cycle arrest at G0/G1 phase [32]. Here, CASP8 is linked to brain cancer.