In addition, vitamin K1 on its own did not induce any cytotoxic effects on the BT325 and U251 cell lines of GBM, but, when combined with sorafenib, marked synergistic anticancer effects were observed, which was shown to work via the suppression of the Raf/MEK/ERK signaling pathway that induces apoptosis [36]. This evidence concerns the gene MAP2K7 and glioblastoma.