CASP8 and cancer: In contrast, the T3 isomers (α-, γ-, and γ-T3) predominantly activate proteins involved in apoptotic signaling, such as Bax, Bid, Caspase-3, Caspase-8, cytochrome c, and TRAIL, while suppressing the Bcl-2 ratio [32,33], which is reported in various cancers [46].