Resveratrol significantly reduced both fasting plasma glucose and insulin levels (mean reductions of −0.29 mmol/L and −0.64 U/mL, respectively), and significantly improved insulin sensitivity (measured by the homeostasis model assessment of insulin resistance [HOMA-IR]) and blood pressure, with more favourable metabolic effects associated with a higher dose of resveratrol (≥100 mg/day) [67]. The gene discussed is INS; the disease is Insulin resistance.