However, based on the analysis of the identified correlations and the results of other authors, the question may still be asked: to what extent do environmental factors, such as caloric content/diet composition (including selenium and iodine supply), influence the induction and severity of inflammation in the early stages of HT, and to what extent is it influenced by endogenous factors, such as the physiological state of the thyroid gland, especially with relatively low levels of anti-TPO antibodies? The gene discussed is TPO; the disease is hematocrit.