IFNG and allergic disease: Additionally, allergic reactions are related to a reduction in the production of anti-inflammatory cytokines (interferon gamma (IFN-γ) and interleukin-12 (IL-12)) and an increase in the production of proinflammatory cytokines (interleukin-4 (IL-4) and interleukin-13 (IL-13)), which play an important part in the differentiation of T cells into T helper (Th) 1 and Th2 cells [6,7].