Kahweol may inhibit the phosphorylation of JNK1/2 and p38 MAPK and the activation of NF- κ B to reduce the expression of phorbol 12-myristate 13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) to promote an anti-tumor effect [36]. Here, MAPK8 is linked to neoplasm.