In addition, the level of Akt phosphorylation in the offspring hippocampus in the HFD group was significantly lower than that in CHD group at all time points (p = 0.0023 on PND 1, p = 0.027 on PND 10 and p = 0.0163 on PND 21, Figure 5C,D). This evidence concerns the gene AKT1 and coronary artery disorder.