Researchers have proven that the activation of AMPK/Sirt-1/PGC-1α helps to promote the biogenesis of mitochondria in adipocytes [36], maintain mitochondrial function, and inhibit oxidative stress, apoptosis, and mitochondrial damage during cerebral ischemia [37] and myocardial ischemia [38]. Here, SIRT1 is linked to brain ischemia.