In the present study, the activities of MnSOD and CAT in the serum and liver of mice in the T2DM group were noticeably reduced, and the protein expression levels of MnSOD and CAT in mice in the T2DM group and HepG2 cells in the HG group were also decreased, while the intervention of punicalagin reversed this change. Here, SOD2 is linked to type 2 diabetes mellitus.