Further, luteolin predominantly suppressed STAT1 and STAT3 phosphorylation in cytokine-induced HT-29 and RAW264.7 cells [171,172,173] and reduced the excessive production of inflammatory synoviocytes in RA patients by regulating the NF-κB- and JAK/STAT-signaling pathways [174]. Here, SOAT1 is linked to rheumatoid arthritis.