However, one study found that quercetin had anti-proliferative effects of IFN-α on cancer cell proliferation due to activating JAK/STAT pathway signaling by inhibiting SHP2 but had no effect on SOCS expression, urging more research into the effect of quercetin on SOCS proteins in the treatment of AD and other skin inflammation [216]. The gene discussed is CISH; the disease is Alzheimer disease.