In relation to skin disorders such as AD and psoriasis, SOCS1 protein overexpression was observed when compared to normal skin, and this overexpression inhibited the IFN-γ-induced transactivation of a STAT1-binding promoter in keratinocytes, proving that SOCS1 protein is a potential target for the treatment of cytokine-induced inflammatory skin disorders [66]. This evidence concerns the gene SOCS1 and inflammatory skin disease.