Oncogenic microRNAs (miRs) such as miR-19, miR-21, and miR-30a-5p were shown to be repressed in glioma cells, which was connected to alterations in the expression of their target genes such as p53, NF-KB, EGFR, STAT3, COX-2, and the PI3K/AKT/mTOR signaling pathway. The gene discussed is TP53; the disease is central nervous system cancer.