Intratumoral vaccination of 2′3′-cGAMP in multiple mice models, such as 4T1 murine breast cancer, HSC-2 squamous cell carcinomas, CT26 murine colon cancer, and B16F10 murine melanoma, resulted in a transient increase in macrophages in the tumor and enhanced expression of TNFα and chemokines in the tumor microenvironment [50,52]. Here, TNF is linked to neoplasm.