In consequence, the designed nicotinamide compound was synthesized and indicated excellent in-vitro VEGFR-2 prohibitory potential (51 nM), promising cytotoxicity against MCF-7 and HCT 116 cancer cell lines with IC50 values of 8.25 and 6.48 μM demonstrating selectivity indexes of 12.89 and 16.41, respectively. Here, KDR is linked to cancer.