In particular, this study utilizes 5 × FAD transgenic mouse models, that contain three AD-linked mutations in human APP and two AD-linked mutations in PSEN1 genes: the Florida (I716V), Swedish (K670N/M671L), and London (V717I) mutations in APP; and the M146L and L286V mutations in PSEN1 [7]. The gene discussed is PSEN1; the disease is Alzheimer disease.