PTGS2 and ovarian carcinoma: Another study showed that berberine could reverse the chemotherapeutic drug VP16-induced repopulation of ovarian cancer cells via blocking the independent phospholipase A2 (iPLA2)-arachidonic acid (AA)-cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) pathway and reversing the increased phosphorylation of focal adhesion kinase (FAK) [102].