For example, berberine alleviated NASH by increasing the intestinal farnesoid X receptor (FXR) and fibroblast growth factor 15 (FGF15) via modulating gut microbiota, especially increasing the relative abundance of Clostridiales, Lactobacillaceae, and Bacteroidale [77]. This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatohepatitis.