In 2009, Yang et al. reported that andrographolide can synergistically induce the apoptosis of 5-fluorouracil (5-FU) via the augmentation of caspase-8, p53 activity, and the significant alteration of the Bax conformation in hepatocellular carcinoma (SMMC-7721) [206]. Here, TP53 is linked to hepatocellular carcinoma.