Hamd-Ghadareh et al. also reported a novel immunosensor for CA 125 cancer marker and OVCAR-3 cells based on a fluorescence resonance energy transfer from aptamer-CDs to an Ab-PAMAM-labeled Au nanoparticles (NPs) heterostructure, which was switched off by the specific interaction of CA125 Ag with aptamer and Ab [53]. The gene discussed is MUC16; the disease is cancer.