As it is known that increased acetylcholine (ACh) activity helps to improve cognitive function in AD, many drugs that can enhance the function of ACh neurons according to various mechanisms of action have been developed, such as agonists for muscarinic ACh receptors, ACh production promoters, and acetylcholinesterase (AChE) inhibitors [9,10]. The gene discussed is ACHE; the disease is Alzheimer disease.