NFKB1 and colorectal cancer: While the treatment of colorectal cancer patients with FOLFOX-6 led to a significant down-regulation of Nrf2, thus making patients more susceptible to oxidative stress and inflammation, the oral co-administration of carnosine exerted a neuroprotective effect against oxaliplatin-induced peripheral neuropathy by targeting the Nrf-2 (up-regulation) and NF-κB (down-regulation) pathways.