MAPK3 and colonic neoplasm: On the one hand, crude group B soyasaponins containing soyasaponins I, II, III, and IV were isolated from soybeans and could induce autophagy of human colon cancer HCT15 by inhibiting the Akt signaling pathway and enhancing the activity of ERK1/2, with an IC50 of about 100 p.p.m. [16,17].