In humans, two studies reported that the consumption of Bifobacterium infantis 35624, B. longum CECT 7347, B. lactis CECT 8145, and L. rhamnosus CECT 8361 helped reduce plasma levels of CRP and TNF-α, modulated the GM with a significantly higher number of beneficial genera, and were also associated with a clinical improvement in lesion severity in psoriasis patients [174,175]. The gene discussed is TNF; the disease is psoriasis.