Immunoregulation promoted by these bacterial factors has been previously reported by Chandhni et al. [60], who showed that the extractable surface proteins derived from Lactiplantibacillus plantarum MTCC 5690, Lactobacillus acidophilus NCFM and Limosilactobacillus fermentum MTCC 5689 ameliorated DSS or TNBS-induced acute intestinal inflammation by increasing immunoregulatory IL10 cytokine and decreasing leukocyte infiltration, TNFα, and IFNγ pro-inflammatory markers [60]. The gene discussed is TNF; the disease is inflammatory response.