In a multiple logistic regression model, we identified a CD4+ T lymphocyte value < 200 cells/μL to be significantly associated with the odds of C. cayetanensis co-infection among PLWH, the adjusted odds ratio was 2.11 (95% CI: 1.17, 3.79), p = 0.01 (Supplementary Figure S1a). This evidence concerns the gene CD4 and coinfection.