Participants with C. cayetanensis co-infection had a significantly higher median HIV-1 viral load in log10 copies/mL (5.0 [2.2–5.6 IQR] vs. 4.1 [1.6–5.3 IQR], p < 0.012, Table 2) and a correspondingly lower CD4+ T cell count/μL (228.0 [91.5–395.5 IQR] vs. 355.0 [163.5–586.5 IQR], p = 0.001) than those without this co-infection. This evidence concerns the gene CD4 and coinfection.