Using these results and ours, the estimated overall CrAg frequency in the region for PLWHIV with <100 CD4 cells/mm3 was 9.2% (IC95% 7.9–10.7%) and 8.1% in those with AHD (IC95% 7.9–10.7%). This evidence concerns the gene AGAP3 and mitochondrial DNA depletion syndrome 4a.